Analytical summary of the Chilean experience of the COVID-19 pandemic, 2020-2022
DOI:
https://doi.org/10.56116/cms.v62.n3.2022.374Keywords:
COVID-19, epidemiology, lethality, reproductive numberAbstract
Goal. To carry out a critical analysis of the two and a half year evolution of the pandemic in Chile, evaluating its relationship with socio-cultural aspects of this country and with the strategies used to mitigate the pandemic.
Methods. We analyzed official data reported by the Chilean Ministry of Health: daily new confirmed cases, cases that required admission to intensive care units (ICUs), deaths attributed to COVID-19, and positive tests (RT-PCR) for SARS. CoV-2. We estimate the reproductive number and lethality throughout the pandemic.
Results. We found four epidemic periods: 1) A first epidemic concentrated in the Metropolitan Region in 2020; 2) A major epidemic throughout the country in 2021, 3) A short-lived outbreak in November-December 2021) and 4) A major epidemic outbreak associated with the O variant. The pandemic has produced high lethality and mortality and a great impact on Health System. The dynamic has been strongly influenced by the typical social movements of Chile, such as vacation periods, festivities and overcrowding. The viral variants of SARS CoV-2 have played an important role in transmission, dominating the original variant (WIV04/2019), and the α variant (UK; B.1.1.7) in the RM Epidemic, the γ variants (P .1) and the Andean variant (λ; C.37) in Epidemic 20/21 and the δ and O variants in the last two outbreaks.
Conclusions Despite vaccination efforts and intervention with non-pharmacological measures, the pandemic in Chile has caused a great impact on the population and hospitals. The strategy was affected in 2020 and 2021 by sociocultural aspects and by the rapid lifting of restrictions under the assumption that population immunity as a result of vaccination would allow a tolerable incidence for health systems. In 2022, it has been strongly dominated by the Omicron variant, with high transmission and low lethality, similar to that of the Influenza epidemics.
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References
Guan W et al. Clinical characteristics of Corona disease 2019 in China. N Engl J Med. 2020; 382(18):1708-20.
Wang J et al. Strengths, Weaknesses, Opportunities and Threats (SWOT) Analysis of China’s Prevention and Control Strategy for the COVID-19 Epidemic.Int J Environ Res Public Health. 2020; doi:10.3390/ijerph17072235. https:// www.mdpi. com/1660-4601/17/7/2235
WHO (2020). Report of the WHO-China Joint Mission on Coronavirus Disease 2019 (COVID-19) https://www.who.int/ publications/ i/item/report-of-the-who- china-joint-mission-on-coronavirus- disea- se-2019-(covid-19).
Hur S, Kang J, Cho M, Lee S, Kang J. (2020). Current strategies for the control of C O V I D - 1 9 inSouth Korea. DO. 10.5851/ fl.2020.e1. https://www.researchgate.net/ publication/340299228_Current_ strate- gies_for_the_control_of_COVID-19_in_ South_Korea.
Lee VL et al. Interrupting transmission of COVID-19: lessons from containment efforts in Singapore. J Travel Med. 2020; https://doi.org/10.1093/jtm/taaa039
HaoR,ZhangW,CaoZ,LiJ,XuQ,YeL, et al. Control strategies and their effect on the COVID-19 pandemic in 2020 in repre- sentative countries. Journal of Biosafety and Biosecurity 2021; 3:76-81.
Chen Q. Analysis of the response to COVID-19 in Australia, New Zealand, and Indonesia: the tale of the three island sta- tes. Health Sciences Journal. 2021; 15: 825
WHO Coronavirus Disease (COVID-19) Dashboard. Ginebra: Organización Mundial de la Salud; 2021 (https://co- vid19.who.int/, consultado el 2 de marzo del 2021).
Draft landscape and tracker of COVID-19 candidate vaccines. Ginebra: Organización Mundial de la Salud; 2021 (https://www. who.int/publications/m/item/draftlands- cape-of-covid-19-candidate-vaccines, con- sultado el 2 de marzo del 2021).
Beaumont, P. Covid-19 vaccine: who are countries prioritizing for first doses? The Guardian, 18 de noviembre del 2020 (ht- tps://www.theguardian.com/world/2020/ nov/18/covid-19-vaccine-who-arecoun- tries-prioritising-for-first-doses, consultado el 2 de marzo del 2021).
WHO SAGE values framework for the allocation and prioritization of COVID-19 vaccination. Ginebra: Organización Mundial de la Salud; 2020 (https://apps. who.int/iris/handle/10665/334299, con- sultado el 2 de marzo del 2021).
Mullard, A. How COVID vaccines are be- ing divvied up around the world. Nature, 30 de noviembre del 2020 (https://www. nature.com/articles/d41586-020-03370-6, consultado el 2 de marzo del 2021).
Organización Panamericana de la Salud. Evaluación de la efectividad de las vacu- nas contra la COVID-19. Orientación provisional.2021; OPS-W/FPL/IM/ COVID-19/21-0028
Our World in Data 2021. https://ourworl- dindata.org/
Kretzschmar ME, Rozhnova G, van Boven M. Isolation and contact tracing can tip the scale to containment of COVID-19 in po- pulations with social distancing. Front Phys 2021; 8: 622485.
Contreras S, Dehning J, Loidolt M, et al. The challenges of containing SARS-CoV-2 via test-trace-and-isolate. Nat Commun 2021; 12: 1–13.
Priesseman V, Balling R, Bauer S, Beutels P, Calero A, Cuschieri S, et al. Towards an European strategy to address the COVID-19 pandemic. The Lancet 2021; 398: 838-839.
Canals M, Cuadrado C, Canals A, Johannessen K, Lefio LA, Bertoglia MP, et al. Epidemic trends, public health respon- se and health system capacity: The Chilean experience in COVID-19 epidemic. 2020; Rev Panam Salud Publica 44, e99. https:// doi.org/10.26633/RPSP.2020.99
Ministerio de Salud de Chle. 2022 (https:// www.gob.cl/coronavirus/cifrasoficiales/, consultado el 3 de Marzo de 2022).
Ministerio de Ciencias de Chile. 2022. (https://github.com/MinCiencia/Datos- COVID19/tree/master/output/produc- to9, consultado el 20 de marzo de 2022).
World Health Organization. 2022.WHO (https://www.who.int/emergencies/disea- ses/novel-coronavirus-2019/situation-re- ports/, consultado el 15 de Marzo de 2022).
Russell T, Hellewell J, Abbott S, Golding N, Gibbs H, Jarvis CI, et al. (2020a). Using a delay-adjusted case fatality ratio to estimate under-reporting. CMMID; London School of Hygiene & Tropical Medicine. CMMID Repository. cmmid.github.io/topics/co- vid19/global_crf_estimates.html.
Russell TW, Hellewell J, Jarvis CI, van Zandvoort K, Abbott S, Ratnayake R, et al. (2020b) Estimating the infection and
Cuad Méd Soc (Chile) 2022, 62 N°3: 5-16
ORIGINALES
case fatality ratio for coronavirus disease (COVID-19) using age-adjusted data from the outbreak on the Diamond Princess crui- se ship. Euro Surveill Doi: 10.2807/1560- 7917.ES.2020.25.12.2000256.
Cori A, Ferguson NM, Fraser C, Cauchemez S. (2013). A new framework and software to estimate time-varying re- production numbers during epidemics. Am J Epidemiol;178(9):1505–1512. https://doi. org/10.1093/aje/kwt133
An der Heiden, M., Buchholz, U. Modellierung von Beispielszenarien der SARS-CoV2-Epidemie 2020 in Deutschland. 2020; DOI 10.25646/6571.2
An der Heiden, M., Hamouda, O. Schätzung der aktuellen Entwicklung der SARSCoV-2-Epidemie in Deutschland – Nowcasting. Epid. Bull. 2020;17:S.10–15. DOI 10.25646/6692
Izadi N, Taherpour N, Mokhayeri Y, et al. The epidemiologic parameters for COVID-19: A Systematic Review and Meta-Analysis. 2020; https://doi. org/10.1101/2020.05.02.20088385doi
Zhang P, Wang T, Xie SX. Meta- analysis of several epidemic characte- ristics of COVID-19.2020; https://doi. org/10.1101/2020.05.31.20118448doi
Alenne M, Yismaw L, Assemie MA, Ketema DB, Gietaneh W, Birhan TY. Serial interval and incubation period of COVID- 19:a systematic review and meta-analysis. Infectious Diseases. 2021; 21:257 https:// doi.org/10.1186/s12879-021-05950-x
Dietz K. Transmission and control of ar- bovirus diseases. In: Ludwig D, Cooke KL editors. Epidemiology. SIAM, Philadelphia, 1975. p. 104-21.
Smith CEG. Prospects for the control of infectious disease. Proc Roy Soc Med 1970; 63:1181–90.
Departamento de Estadísticas e Información en Salud. Ministerio de Salud de Chile. https://informesdeis.minsal.cl/, consultado el 15 de Marzo de 2022).
Li Y, Undurraga EA, Zubizarreta J. Effectiveness of Localized Lockdowns in the COVID-19 Pandemic. Amer J Epidemiol.2022; (submittted).
Mena GE, Martinez PP, Mahmud AS,Marquet PA, Buckee CO, Santillana M. Socioeconomic status determines COVID-19 incidence and related mortality in Santiago, Chile. Science 2021; 10.1126/ science.abg5298
ICOVID Chile.(https://www.icovidchile. cl/, consultado el 20 de Marzo de 2022).
Angulo J, Martinez-Valdebenito C, Pardo- Roa C, Almonacid LI, Fuentes-Luppichini E, Contreras AM, et al. Assesment of mu- tations associated with genomic variants SARS-CoV-2: RT-qPCR as a rapid and affordable tool to monitoring know circu- lating variants in Chile, 2021. Frontiers in Medicine. 9: 841073.
Laboratorio de Infectología yVirología Molecular, Red UC Christus, Facultad de Medicina, Pontificia Universidad Católica de Chile.(https://www.viris,uc.cl, consulta- do el 20 de febrero de 2022).
Iuliano AD, Roguski K, Chang HH, Muscatello DJ, Palekar R, Tempia S, et al. Estimates of global seasonal influenza-as- sociated respiratory mortality: a modelling study. Lancet 2018; 391: 1285-1300.
Li CK, Choi BC, Wong TW. Influenza- related deaths and hospitalizations in Hong Kong: a subtropical area. Public Health. 2006;120(6):517–524.
Cuadrado C, Vidal F, Pacheco J, Flores- Alvarado S. Cancer care Access in Chile ́s vulnerable populations du- ring the COVID-19 pandemic. AJPH 2022; e1-e11. https://doi.org/10.2105/ AJPH.2021.306587
Jara A, Undurraga EA, González C, Paredes F, Fontecilla T, Jara G, et al. Effectiveness of an Inactivated SARS-CoV-2 Vaccine in Chile. N Engl J Med. 2021; DOI: 10.1056/ NEJMoa2107715
Sauré D, O ́Ryan M, Torres JP, Zuñiga M, Santelices E, Basso LS. Dynamic IgG se- ropositivity after rollout of CoronaVac and BNT162b2 COVID-19 vaccines in Chile: a sentinel surveillance study 40. Lancet Infect Dis 2022; 22: 56–63.
Ito K, Piantham C, Nishiura H. Relative instantaneous reproduction number of Omicron SARS-CoV-2 variant with respect to the Delta variant in Denmark. J Med Virol 2022; 94:2265-2268.
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